Abstract
(Figure Presented) On home ground: The reaction mechanisms of bacterial alkane-oxidizing cytochrome P450s were determined in their native environment using a novel diagnostic substrate probe, bicyclohexane, in whole cells and cell-free extracts (see picture). Purified P450cam also oxidizes bicyclohexane. Clear evidence for a substrate-based radical with a lifetime of 75-250 ps was obtained.
Original language | English (US) |
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Pages (from-to) | 8192-8194 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 45 |
Issue number | 48 |
DOIs | |
State | Published - Dec 11 2006 |
All Science Journal Classification (ASJC) codes
- General Chemistry
- Catalysis
Keywords
- Alkanes
- Cytochromes
- Oxidation
- Radical ions
- Reaction mechanisms