The contraction of time and space in remote chromosomal interactions

Research output: Contribution to journalShort survey

4 Scopus citations

Abstract

Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B cells. Despite the huge distances separating V coding sequences from D-J sequences (∼2 Mb), the authors document an astonishingly rapid rate of remote associations. The key to speed is contraction of the Igh chromosomal domain. These findings provide a foundation for understanding long-range regulatory interactions in a variety of developmental processes, including the patterning of vertebrate limbs.

Original languageEnglish (US)
Pages (from-to)243-244
Number of pages2
JournalCell
Volume158
Issue number2
DOIs
StatePublished - Jul 17 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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