The contraction of time and space in remote chromosomal interactions

Michael Levine

doi:10.1016/j.cell.2014.06.039

The contraction of time and space in remote chromosomal interactions

Michael Levine

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B cells. Despite the huge distances separating V coding sequences from D-J sequences (∼2 Mb), the authors document an astonishingly rapid rate of remote associations. The key to speed is contraction of the Igh chromosomal domain. These findings provide a foundation for understanding long-range regulatory interactions in a variety of developmental processes, including the patterning of vertebrate limbs.

Original language	English (US)
Pages (from-to)	243-244
Number of pages	2
Journal	Cell
Volume	158
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2014.06.039
State	Published - Jul 17 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2014.06.039

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title = "The contraction of time and space in remote chromosomal interactions",

abstract = "Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B cells. Despite the huge distances separating V coding sequences from D-J sequences (∼2 Mb), the authors document an astonishingly rapid rate of remote associations. The key to speed is contraction of the Igh chromosomal domain. These findings provide a foundation for understanding long-range regulatory interactions in a variety of developmental processes, including the patterning of vertebrate limbs.",

author = "Michael Levine",

note = "Funding Information: M.L. is funded by grants from the National Institutes of Health (GM46638, GM34431, and NS076542).",

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T1 - The contraction of time and space in remote chromosomal interactions

AU - Levine, Michael

N1 - Funding Information: M.L. is funded by grants from the National Institutes of Health (GM46638, GM34431, and NS076542).

PY - 2014/7/17

Y1 - 2014/7/17

N2 - Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B cells. Despite the huge distances separating V coding sequences from D-J sequences (∼2 Mb), the authors document an astonishingly rapid rate of remote associations. The key to speed is contraction of the Igh chromosomal domain. These findings provide a foundation for understanding long-range regulatory interactions in a variety of developmental processes, including the patterning of vertebrate limbs.

AB - Lucas et al. report the visualization of V(D)J recombination of the immunoglobulin heavy-chain gene (Igh) in living pro-B cells. Despite the huge distances separating V coding sequences from D-J sequences (∼2 Mb), the authors document an astonishingly rapid rate of remote associations. The key to speed is contraction of the Igh chromosomal domain. These findings provide a foundation for understanding long-range regulatory interactions in a variety of developmental processes, including the patterning of vertebrate limbs.

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U2 - 10.1016/j.cell.2014.06.039

DO - 10.1016/j.cell.2014.06.039

M3 - Short survey

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VL - 158

SP - 243

EP - 244

JO - Cell

JF - Cell

IS - 2

ER -

The contraction of time and space in remote chromosomal interactions

Abstract

All Science Journal Classification (ASJC) codes

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