The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

  • Patrick S. Ward
  • , Jay Patel
  • , David R. Wise
  • , Omar Abdel-Wahab
  • , Bryson D. Bennett
  • , Hilary A. Coller
  • , Justin R. Cross
  • , Valeria R. Fantin
  • , Cyrus V. Hedvat
  • , Alexander E. Perl
  • , Joshua D. Rabinowitz
  • , Martin Carroll
  • , Shinsan M. Su
  • , Kim A. Sharp
  • , Ross L. Levine
  • , Craig B. Thompson

Research output: Contribution to journal › Article › peer-review

1792 Scopus citations

Fingerprint

Dive into the research topics of 'The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate'. Together they form a unique fingerprint.

Keyphrases

Pharmacology, Toxicology and Pharmaceutical Science

Neuroscience

Biochemistry, Genetics and Molecular Biology