The chemical synthesis of proteins

Tom W. Muir, Stephen B.H. Kent

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Total chemical synthesis is developing as an important approach to the construction of native proteins and their analogs for the study of the structural basis of biochemical activity. In the past year, a radical departure from conventional synthetic approaches has led to a renaissance in this field. The inherent simplicity of these new modes of protein construction will allow large synthetic proteins (> 200 amino acids in length) to be routinely assembled; this will vastly expand the repertoire of protein molecules accessible to research.

Original languageEnglish (US)
Pages (from-to)420-427
Number of pages8
JournalCurrent Opinion in Biotechnology
Issue number4
StatePublished - Aug 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biotechnology
  • Biomedical Engineering


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