The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

Magdalena Murawska; Tamas Schauer; Atsushi Matsuda; Marcus D. Wilson; Thomas Pysik; Felix Wojcik; Tom W. Muir; Yasushi Hiraoka; Tobias Straub; Andreas G. Ladurner

doi:10.1016/j.molcel.2019.11.016

The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

Magdalena Murawska
, Tamas Schauer
, Atsushi Matsuda
, Marcus D. Wilson
, Thomas Pysik
, Felix Wojcik
, Tom W. Muir
, Yasushi Hiraoka
, Tobias Straub
, Andreas G. Ladurner

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The essential histone chaperone FACT controls chromatin integrity in cooperation with H2B ubiquitination. Murawska et al. reveal how H2Bub regulates FACT activity within gene bodies and identify a novel role for the FACT complex at highly compacted chromosomal regions.

Original language	English (US)
Pages (from-to)	501-513.e7
Journal	Molecular Cell
Volume	77
Issue number	3
DOIs	https://doi.org/10.1016/j.molcel.2019.11.016
State	Published - Feb 6 2020

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

Keywords

FACT
H2B ubiquitination
S. pombe
chromatin structure
histone chaperone

Access to Document

10.1016/j.molcel.2019.11.016

Cite this

@article{f367aeb86e9d4de6a624e985c19ce84e,

title = "The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions",

abstract = "The essential histone chaperone FACT controls chromatin integrity in cooperation with H2B ubiquitination. Murawska et al. reveal how H2Bub regulates FACT activity within gene bodies and identify a novel role for the FACT complex at highly compacted chromosomal regions.",

keywords = "FACT, H2B ubiquitination, S. pombe, chromatin structure, histone chaperone",

author = "Magdalena Murawska and Tamas Schauer and Atsushi Matsuda and Wilson, \{Marcus D.\} and Thomas Pysik and Felix Wojcik and Muir, \{Tom W.\} and Yasushi Hiraoka and Tobias Straub and Ladurner, \{Andreas G.\}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2020",

month = feb,

day = "6",

doi = "10.1016/j.molcel.2019.11.016",

language = "English (US)",

volume = "77",

pages = "501--513.e7",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

AU - Murawska, Magdalena

AU - Schauer, Tamas

AU - Matsuda, Atsushi

AU - Wilson, Marcus D.

AU - Pysik, Thomas

AU - Wojcik, Felix

AU - Muir, Tom W.

AU - Hiraoka, Yasushi

AU - Straub, Tobias

AU - Ladurner, Andreas G.

PY - 2020/2/6

Y1 - 2020/2/6

N2 - The essential histone chaperone FACT controls chromatin integrity in cooperation with H2B ubiquitination. Murawska et al. reveal how H2Bub regulates FACT activity within gene bodies and identify a novel role for the FACT complex at highly compacted chromosomal regions.

AB - The essential histone chaperone FACT controls chromatin integrity in cooperation with H2B ubiquitination. Murawska et al. reveal how H2Bub regulates FACT activity within gene bodies and identify a novel role for the FACT complex at highly compacted chromosomal regions.

KW - FACT

KW - H2B ubiquitination

KW - S. pombe

KW - chromatin structure

KW - histone chaperone

UR - https://www.scopus.com/pages/publications/85078718732

UR - https://www.scopus.com/pages/publications/85078718732#tab=citedBy

U2 - 10.1016/j.molcel.2019.11.016

DO - 10.1016/j.molcel.2019.11.016

M3 - Article

C2 - 31837996

AN - SCOPUS:85078718732

SN - 1097-2765

VL - 77

SP - 501-513.e7

JO - Molecular Cell

JF - Molecular Cell

IS - 3

ER -

The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

Other files and links

Fingerprint

Cite this