The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

Magdalena Murawska, Tamas Schauer, Atsushi Matsuda, Marcus D. Wilson, Thomas Pysik, Felix Wojcik, Tom W. Muir, Yasushi Hiraoka, Tobias Straub, Andreas G. Ladurner

Research output: Contribution to journalArticle

Abstract

The essential histone chaperone FACT controls chromatin integrity in cooperation with H2B ubiquitination. Murawska et al. reveal how H2Bub regulates FACT activity within gene bodies and identify a novel role for the FACT complex at highly compacted chromosomal regions.

Original languageEnglish (US)
Pages (from-to)501-513.e7
JournalMolecular Cell
Volume77
Issue number3
DOIs
StatePublished - Feb 6 2020

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Keywords

  • FACT
  • H2B ubiquitination
  • S. pombe
  • chromatin structure
  • histone chaperone

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    Murawska, M., Schauer, T., Matsuda, A., Wilson, M. D., Pysik, T., Wojcik, F., Muir, T. W., Hiraoka, Y., Straub, T., & Ladurner, A. G. (2020). The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Molecular Cell, 77(3), 501-513.e7. https://doi.org/10.1016/j.molcel.2019.11.016