The cell biology of planar cell polarity

Research output: Contribution to journalReview article

139 Scopus citations

Abstract

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between neighboring cells. Recent progress has been made toward understanding how protein transport, endocytosis, and intercellular interactions contribute to asymmetric PCP protein localization. Additionally, the functions of gradients and mechanical forces as global cues that bias PCP orientation are beginning to be elucidated. Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level.

Original languageEnglish (US)
Pages (from-to)171-179
Number of pages9
JournalJournal of Cell Biology
Volume207
Issue number2
DOIs
StatePublished - 2014

All Science Journal Classification (ASJC) codes

  • Cell Biology

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