Abstract
The antimycobacterial efficacy of the abyssomicin C family of natural products, in addition to a key synthetic intermediate, has been investigated given their reported inhibition of Bacillus subtilis p-aminobenzoate biosynthesis. The naturally occurring (-)-abyssomicin C and its atropisomer were found to exhibit low micromolar growth inhibition against the relatively fast-growing and non-virulent Mycobacterium smegmatis and the vaccine strain Mycobacterium bovis BCG, while their antipodes were slightly less active. (-)-Abyssomicin C and its atropisomer were particularly efficacious against Mycobacterium tuberculosis H37Rv, exhibiting MIC values of 3.6 and 7.2 μM, respectively. More specifically, (-)-abyssomicin C was bactericidal. This complex natural product and its analogs, thus, hold promise as chemical tools in the study of M. tuberculosis metabolism.
Original language | English (US) |
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Pages (from-to) | 298-300 |
Number of pages | 3 |
Journal | Tuberculosis |
Volume | 90 |
Issue number | 5 |
DOIs | |
State | Published - Sep 2010 |
All Science Journal Classification (ASJC) codes
- Microbiology (medical)
- Infectious Diseases
- Microbiology
- Immunology
Keywords
- Abyssomicin
- Mycobacterium tuberculosis
- p-Aminobenzoate metabolism