TY - JOUR
T1 - The 2022 Report on the Human Proteome from the HUPO Human Proteome Project
AU - Omenn, Gilbert S.
AU - Lane, Lydie
AU - Overall, Christopher M.
AU - Pineau, Charles
AU - Packer, Nicolle H.
AU - Cristea, Ileana M.
AU - Lindskog, Cecilia
AU - Weintraub, Susan T.
AU - Orchard, Sandra
AU - Roehrl, Michael H.A.
AU - Nice, Edouard
AU - Liu, Siqi
AU - Bandeira, Nuno
AU - Chen, Yu Ju
AU - Guo, Tiannan
AU - Aebersold, Ruedi
AU - Moritz, Robert L.
AU - Deutsch, Eric W.
N1 - Publisher Copyright:
© 2022 American Chemical Society.
PY - 2023/4/7
Y1 - 2023/4/7
N2 - The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 407 (93.2%) of the 19 750 predicted proteins coded in the human genome, a net gain of 50 since 2021 from data sets generated around the world and reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 78 from 1421 to 1343. This represents continuing experimental progress on the human proteome parts list across all the chromosomes, as well as significant reclassifications. Meanwhile, applying proteomics in a vast array of biological and clinical studies continues to yield significant findings and growing integration with other omics platforms. We present highlights from the Chromosome-Centric HPP, Biology and Disease-driven HPP, and HPP Resource Pillars, compare features of mass spectrometry and Olink and Somalogic platforms, note the emergence of translation products from ribosome profiling of small open reading frames, and discuss the launch of the initial HPP Grand Challenge Project, “A Function for Each Protein”.
AB - The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 407 (93.2%) of the 19 750 predicted proteins coded in the human genome, a net gain of 50 since 2021 from data sets generated around the world and reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 78 from 1421 to 1343. This represents continuing experimental progress on the human proteome parts list across all the chromosomes, as well as significant reclassifications. Meanwhile, applying proteomics in a vast array of biological and clinical studies continues to yield significant findings and growing integration with other omics platforms. We present highlights from the Chromosome-Centric HPP, Biology and Disease-driven HPP, and HPP Resource Pillars, compare features of mass spectrometry and Olink and Somalogic platforms, note the emergence of translation products from ribosome profiling of small open reading frames, and discuss the launch of the initial HPP Grand Challenge Project, “A Function for Each Protein”.
KW - Biology and Disease-HPP (B/D-HPP)
KW - Grand Challenge Project
KW - Human Protein Atlas
KW - Human Proteome Project (HPP)
KW - Mass Spectrometry Interactive Virtual Environment (MassIVE)
KW - PeptideAtlas
KW - Ribo-Seq
KW - chromosome-centric HPP (C-HPP)
KW - missing proteins (MP)
KW - neXtProt protein existence (PE metrics)
KW - non-MS PE1 proteins
KW - small open reading frames (smORFs)
KW - uncharacterized protein existence 1 (uPE1)
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U2 - 10.1021/acs.jproteome.2c00498
DO - 10.1021/acs.jproteome.2c00498
M3 - Review article
C2 - 36318223
AN - SCOPUS:85141716437
SN - 1535-3893
VL - 22
SP - 1024
EP - 1042
JO - Journal of Proteome Research
JF - Journal of Proteome Research
IS - 4
ER -