The σ(E) and Cpx regulatory pathways: Overlapping but distinct envelope stress responses

Tracy L. Raivio, Thomas J. Silhavy

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

The Cpx and σ(E) extracytoplasmic stress responses sense and respond to misfolded proteins in the bacterial envelope. Recent studies have highlighted differences between these regulatory pathways in terms of activating signals, mechanisms of signal transduction and the nature of the responses. Cumulatively, the findings suggest distinct physiological roles for these partially overlapping envelope stress responses. The σ(E) pathway is essential for survival and is primarily responsible for monitoring and responding to alterations in outer membrane protein folding. Mounting evidence suggests that the Cpx regulon may have been adapted to ensure properly timed expression and assembly of adhesive organelles.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalCurrent opinion in microbiology
Volume2
Issue number2
DOIs
StatePublished - Apr 1999

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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