Ten‐Membered Ring Enediynes with Remarkable Chemical and Biological Profiles

K. C. Nicolaou, Erik J. Sorensen, Robert Discordia, Chan‐Kou ‐K Hwang, Robert G. Bergman, Robert E. Minto, Kamal N. Bharucha

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Abstract

The large effects of minimal structural variations are demonstrated by enediynes 1. At 50 °C the cis isomer cyclizes much faster (t1/2 = 4 h) than the trans isomer (t1/2 = 22 h). The carbonate derivative of trans‐l is stable even for several hours at 100 °C. The exploration of the chemistry of cyclic enediynes is prompted by their DNA‐cleaving properties. (Figure Presented.)

Original languageEnglish (US)
Pages (from-to)1044-1046
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume31
Issue number8
DOIs
StatePublished - Aug 1992

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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    Nicolaou, K. C., Sorensen, E. J., Discordia, R., Hwang, CK. K., Bergman, R. G., Minto, R. E., & Bharucha, K. N. (1992). Ten‐Membered Ring Enediynes with Remarkable Chemical and Biological Profiles. Angewandte Chemie International Edition in English, 31(8), 1044-1046. https://doi.org/10.1002/anie.199210441