Ten‐Membered Ring Enediynes with Remarkable Chemical and Biological Profiles

K. C. Nicolaou, Erik J. Sorensen, Robert Discordia, Chan‐Kou ‐K Hwang, Robert G. Bergman, Robert E. Minto, Kamal N. Bharucha

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


The large effects of minimal structural variations are demonstrated by enediynes 1. At 50 °C the cis isomer cyclizes much faster (t1/2 = 4 h) than the trans isomer (t1/2 = 22 h). The carbonate derivative of trans‐l is stable even for several hours at 100 °C. The exploration of the chemistry of cyclic enediynes is prompted by their DNA‐cleaving properties. (Figure Presented.)

Original languageEnglish (US)
Pages (from-to)1044-1046
Number of pages3
JournalAngewandte Chemie International Edition in English
Issue number8
StatePublished - Aug 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry


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