Temporal waves of coherent gene expression during Drosophila embryogenesis

Ilya Papatsenko, Mike Levine, Dmitri Papatsenko

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Motivation: Animal development depends on localized patterns of gene expression. Whole-genome methods permit the global identification of differential expression patterns. However, most gene-expression-clustering methods focus on the analysis of entire expression profiles, rather than temporal segments or time windows. Results: In the current study, local clustering of temporal time windows was applied to developing embryos of the fruitfly, Drosophila melanogaster. Large-scale developmental events, involving temporal activation of hundreds of genes, were identified as discrete gene clusters. The time-duration analysis revealed six temporal waves of coherent gene expression during Drosophila embryogenesis. The most powerful expression waves preceded major morphogenetic movements, such as germ band elongation and dorsal closure. These waves of gene expression coincide with the inhibition of maternal transcripts during early development, the specification of ectoderm, differentiation of the nervous system, differentiation of the digestive tract, deposition of the larval cuticle and the reorganization of the cytoskeleton during global morphogenetic events. We discuss the implications of these findings with respect to the gene regulatory networks governing Drosophila development.

Original languageEnglish (US)
Article numberbtq513
Pages (from-to)2731-2736
Number of pages6
Issue number21
StatePublished - Nov 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Computational Mathematics
  • Molecular Biology
  • Biochemistry
  • Statistics and Probability
  • Computer Science Applications
  • Computational Theory and Mathematics


Dive into the research topics of 'Temporal waves of coherent gene expression during Drosophila embryogenesis'. Together they form a unique fingerprint.

Cite this