@article{b80bf6b4952a4a1882035afac27f16d8,
title = "Temporal processing and context dependency in caenorhabditis elegans response to mechanosensation",
abstract = "A quantitative understanding of how sensory signals are transformed into motor outputs places useful constraints on brain function and helps to reveal the brain{\textquoteright}s underlying computations. We investigate how the nematode Caenorhabditis elegans responds to time-varying mechanosensory signals using a high-throughput optogenetic assay and automated behavior quantification. We find that the behavioral response is tuned to temporal properties of mechanosensory signals, such as their integral and derivative, that extend over many seconds. Mechanosensory signals, even in the same neurons, can be tailored to elicit different behavioral responses. Moreover, we find that the animal{\textquoteright}s response also depends on its behavioral context. Most dramatically, the animal ignores all tested mechanosensory stimuli during turns. Finally, we present a linear-nonlinear model that predicts the animal{\textquoteright}s behavioral response to stimulus.",
author = "Mochi Liu and Sharma, {Anuj K.} and Shaevitz, {Joshua W.} and Leifer, {Andrew M.}",
note = "Funding Information: We thank Marc Gershow (NYU) and Gordon Berman (Emory) for productive discussions and troubleshooting. We also thank Mala Murthy and Jonathan Pillow, both of Princeton University, for productive discussions and feedback. Alicia Castillo Bahena and Tayla Duarte contributed to preliminary studies of this work. This work was supported by grants from the Simons Foundation (SCGB #324285 and SCGB #543003, to AML). This work was also supported by Princeton University{\textquoteright}s Dean for Research Innovation Fund (to AML and JWS). Research reported in this publication was supported by the National Human Genome Research Institute of the National Institutes of Health under Award Number T32HG003284. Some strains were provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} Liu et al.",
year = "2018",
month = jun,
day = "26",
doi = "10.7554/eLife.36419",
language = "English (US)",
volume = "7",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}