Temporal and spatial regulation of integrins during development

Christopher M. Meighan, Jean E. Schwarzbauer

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

Integrin receptors for extracellular matrix (ECM) are critical determinants of biological processes. Regulation of integrin expression is one way for cells to respond to changes in the ECM, to integrate intracellular signals, and to obtain appropriate adhesion for cell motility, proliferation, and differentiation. Transcriptional and post-translational mechanisms for changing the integrin repertoire at the cell surface have recently been described. These mechanisms work through transcriptional regulation that alters the proportions of one integrin relative to another, referred to as integrin switching, or through localized regulation of integrin-ECM interactions, thus providing exquisite control over cell rearrangements during tissue morphogenesis and remodeling. These integrin regulatory pathways may also be important targets in such emerging fields as tissue engineering and regenerative medicine.

Original languageEnglish (US)
Pages (from-to)520-524
Number of pages5
JournalCurrent Opinion in Cell Biology
Volume20
Issue number5
DOIs
StatePublished - Oct 2008

All Science Journal Classification (ASJC) codes

  • Cell Biology

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