TY - JOUR
T1 - Temporal and spatial regulation of integrins during development
AU - Meighan, Christopher M.
AU - Schwarzbauer, Jean E.
N1 - Funding Information:
The authors acknowledge support from the National Institutes of Health (R01 GM059383 and NIGMS Cell Migration Consortium U54 GM064346). We also thank Drs Christopher Wylie, Guy Tanentzapf, and Katherine Kragtorp for generously providing their images.
PY - 2008/10
Y1 - 2008/10
N2 - Integrin receptors for extracellular matrix (ECM) are critical determinants of biological processes. Regulation of integrin expression is one way for cells to respond to changes in the ECM, to integrate intracellular signals, and to obtain appropriate adhesion for cell motility, proliferation, and differentiation. Transcriptional and post-translational mechanisms for changing the integrin repertoire at the cell surface have recently been described. These mechanisms work through transcriptional regulation that alters the proportions of one integrin relative to another, referred to as integrin switching, or through localized regulation of integrin-ECM interactions, thus providing exquisite control over cell rearrangements during tissue morphogenesis and remodeling. These integrin regulatory pathways may also be important targets in such emerging fields as tissue engineering and regenerative medicine.
AB - Integrin receptors for extracellular matrix (ECM) are critical determinants of biological processes. Regulation of integrin expression is one way for cells to respond to changes in the ECM, to integrate intracellular signals, and to obtain appropriate adhesion for cell motility, proliferation, and differentiation. Transcriptional and post-translational mechanisms for changing the integrin repertoire at the cell surface have recently been described. These mechanisms work through transcriptional regulation that alters the proportions of one integrin relative to another, referred to as integrin switching, or through localized regulation of integrin-ECM interactions, thus providing exquisite control over cell rearrangements during tissue morphogenesis and remodeling. These integrin regulatory pathways may also be important targets in such emerging fields as tissue engineering and regenerative medicine.
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U2 - 10.1016/j.ceb.2008.05.010
DO - 10.1016/j.ceb.2008.05.010
M3 - Review article
C2 - 18603422
AN - SCOPUS:50849142875
SN - 0955-0674
VL - 20
SP - 520
EP - 524
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 5
ER -