SV-S, a cloned small plaque mutant of Sindbis virus derived from persistently infected A odes aegypti cell cultures, was shown also to be an RNA temperature-sensitive mutant. It interfered with the replication of SV-W at the nonpermissive temperature as well as the permissive temperature, but did not depress net viral RNA synthesis in cells coinfected with SV-W.
All Science Journal Classification (ASJC) codes
- Infectious Diseases
- Aedes aegypti cells
- Persistent infection
- Sindbis virus mutant