Temperature sensitivity of a sindbis virus mutant isolated from persistently infected Aedes aegypti cell culture

Victor Stollar, Joseph Peleg, Thomas E. Shenk

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

SV-S, a cloned small plaque mutant of Sindbis virus derived from persistently infected A odes aegypti cell cultures, was shown also to be an RNA temperature-sensitive mutant. It interfered with the replication of SV-W at the nonpermissive temperature as well as the permissive temperature, but did not depress net viral RNA synthesis in cells coinfected with SV-W.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalIntervirology
Volume2
Issue number5-6
DOIs
StatePublished - Jan 1 1973
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Keywords

  • Aedes aegypti cells
  • Persistent infection
  • Sindbis virus mutant

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