Telomeric position effect in yeast

Lisa L. Sandell; Virginia A. Zakian

doi:10.1016/0962-8924(92)90138-D

Telomeric position effect in yeast

Lisa L. Sandell, Virginia A. Zakian

Molecular Biology

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

Telomeres are the physical ends of chromosomes. In yeast, when a gene is placed near a telomere, its transcription is repressed. Genes under the influence of this telomeric position effects switch between a repressed state and a transcriptionally active state, each of which is stable for many cell generations. Telomeric position effect may provide a model system for the study of heritable gene regulation in other, more complex organisms.

Original language	English (US)
Pages (from-to)	10-14
Number of pages	5
Journal	Trends in Cell Biology
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/0962-8924(92)90138-D
State	Published - Jan 1992

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1016/0962-8924(92)90138-D

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title = "Telomeric position effect in yeast",

abstract = "Telomeres are the physical ends of chromosomes. In yeast, when a gene is placed near a telomere, its transcription is repressed. Genes under the influence of this telomeric position effects switch between a repressed state and a transcriptionally active state, each of which is stable for many cell generations. Telomeric position effect may provide a model system for the study of heritable gene regulation in other, more complex organisms.",

author = "Sandell, {Lisa L.} and Zakian, {Virginia A.}",

note = "Funding Information: We thank R. Levis and R. Sternglanz for very helpful comments on the manuscript, and Joe Gall and Nancy Hutchison for photographs used in Fig. 1. Work from our laboratory is sup- ported by grants from the National Institutes of Health. L. L. S. is supported in part by an NIH training grant, Genetic Approaches to Aging Research.",

year = "1992",

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AU - Sandell, Lisa L.

AU - Zakian, Virginia A.

N1 - Funding Information: We thank R. Levis and R. Sternglanz for very helpful comments on the manuscript, and Joe Gall and Nancy Hutchison for photographs used in Fig. 1. Work from our laboratory is sup- ported by grants from the National Institutes of Health. L. L. S. is supported in part by an NIH training grant, Genetic Approaches to Aging Research.

PY - 1992/1

Y1 - 1992/1

N2 - Telomeres are the physical ends of chromosomes. In yeast, when a gene is placed near a telomere, its transcription is repressed. Genes under the influence of this telomeric position effects switch between a repressed state and a transcriptionally active state, each of which is stable for many cell generations. Telomeric position effect may provide a model system for the study of heritable gene regulation in other, more complex organisms.

AB - Telomeres are the physical ends of chromosomes. In yeast, when a gene is placed near a telomere, its transcription is repressed. Genes under the influence of this telomeric position effects switch between a repressed state and a transcriptionally active state, each of which is stable for many cell generations. Telomeric position effect may provide a model system for the study of heritable gene regulation in other, more complex organisms.

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Telomeric position effect in yeast

Abstract

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