TY - JOUR
T1 - TATA-binding protein-independent initiation
T2 - YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA
AU - Usheva, Anny
AU - Shenk, Thomas
PY - 1994/3/25
Y1 - 1994/3/25
N2 - YY1 is a zinc finger transcription factor whose DNA-binding motif exhibits the properties of an initiator element. Only three factors were required to direct specific basal transcription on a supercoiled template DNA carrying the YY1 initiator: YY1, general transcription factor IIB, and RNA polymerase II. This minimal in vitro reaction did not require the TATA-binding protein (TBP). We propose that, under appropriate conditions, YY1 can function like TBP, as a factor that binds to the core promoter and recruits the polymerase to the initiation complex.
AB - YY1 is a zinc finger transcription factor whose DNA-binding motif exhibits the properties of an initiator element. Only three factors were required to direct specific basal transcription on a supercoiled template DNA carrying the YY1 initiator: YY1, general transcription factor IIB, and RNA polymerase II. This minimal in vitro reaction did not require the TATA-binding protein (TBP). We propose that, under appropriate conditions, YY1 can function like TBP, as a factor that binds to the core promoter and recruits the polymerase to the initiation complex.
UR - http://www.scopus.com/inward/record.url?scp=0028223852&partnerID=8YFLogxK
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U2 - 10.1016/0092-8674(94)90387-5
DO - 10.1016/0092-8674(94)90387-5
M3 - Article
C2 - 8137426
AN - SCOPUS:0028223852
VL - 76
SP - 1115
EP - 1121
JO - Cell
JF - Cell
SN - 0092-8674
IS - 6
ER -