@article{09f5c28f106a4db48ad56074c671b21b,
title = "Task-Dependent Changes in the Large-Scale Dynamics and Necessity of Cortical Regions",
abstract = "Pinto et al. show that more complex perceptual decisions engage more diverse and spatially distributed computations across the cortex than simpler decisions, even when sensory stimuli and motor output are held constant.",
keywords = "RNN, cortex, decision making, evidence accumulation, mouse behavior, optogenetics, virtual reality, widefield Ca imaging, working memory",
author = "Lucas Pinto and Kanaka Rajan and Brian DePasquale and Thiberge, {Stephan Y.} and Tank, {David W.} and Brody, {Carlos D.}",
note = "Funding Information: We thank S.A. Koay for discussions and visual mapping software; B.B. Scott, A. Piet, and E.S. Carter for discussions; S. Stein and S. Baptista for technical support; and H.K. Inagaki and K. Svoboda for advice regarding the cleared skull preparation. We also thank P.D. Rich, E. Dennis, A. Riordan, and E. Nieh for helpful comments on the manuscript. The LED strobing Arduino software was modified from code provided by M. Shaik and E.M.C. Hillman. B.E. Engelhard built some of the VR training setups. This work was supported by NIH grants U01NS090541, U19NS104648, and F32NS101871 (to L.P.) and K99MH120047 (to L.P.). L.P. performed the experiments and analyzed the data. K.R. and B.D. developed the RNN models. S.Y.T. and D.W.T. designed the VR and optical setups. L.P. wrote the manuscript with input from C.D.B. and D.W.T. L.P. C.D.B. and D.W.T. conceived the project. The authors declare no competing financial interests. Funding Information: We thank S.A. Koay for discussions and visual mapping software; B.B. Scott, A. Piet, and E.S. Carter for discussions; S. Stein and S. Baptista for technical support; and H.K. Inagaki and K. Svoboda for advice regarding the cleared skull preparation. We also thank P.D. Rich, E. Dennis, A. Riordan, and E. Nieh for helpful comments on the manuscript. The LED strobing Arduino software was modified from code provided by M. Shaik and E.M.C. Hillman. B.E. Engelhard built some of the VR training setups. This work was supported by NIH grants U01NS090541 , U19NS104648 , and F32NS101871 (to L.P.) and K99MH120047 (to L.P.). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = nov,
day = "20",
doi = "10.1016/j.neuron.2019.08.025",
language = "English (US)",
volume = "104",
pages = "810--824.e9",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}