Tailoring polymeric hydrogels through cyclodextrin host-guest complexation

Xuhong Guo, Jie Wang, Li Li, Duc Truc Pham, Philip Clements, Stephen F. Lincoln, Bruce L. May, Oingchuan Chen, Li Zheng, Robert K. Prud'Homme

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


A close correlation between molecular-level interactions and macroscopic characteristics of polymer networks exists. The characteristics of the polymeric hydrogels assembled from β-cyclodextrin (β-CD) and adamantyl (AD) substituted poly(acrylate)s can be tailored through selective host-guest complexation between β-CD and AD substituents and their tethers. Dominantly, steric effects and competitive intra- and intermolecular host-guest complexation are found to control poly(acrylate) isomeric inter-strand linkage in polymer network formation. This understanding of the factors involved in polymeric hydrogel formation points the way towards the construction of increasingly sophisticated biocompatible materials. (Figure Presented)

Original languageEnglish (US)
Pages (from-to)300-304
Number of pages5
JournalMacromolecular Rapid Communications
Issue number3
StatePublished - Feb 2 2010

All Science Journal Classification (ASJC) codes

  • Materials Chemistry
  • Polymers and Plastics
  • Organic Chemistry


  • Cyclodextrin
  • Host-guest complexation
  • Hydrogels
  • Polyelectrolytes


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