Systems-level questions in Drosophila oogenesis

N. Yakoby, C. A. Bristow, I. Gouzman, M. P. Rossi, Y. Gogotsi, T. Schüpbach, S. Y. Shvartsman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


This paper describes computational and experimental work on pattern formation in Drosophila egg development (oogenesis), an established experimental model for studying cell fate diversification in developing tissues. Epidermal growth factor receptor (EGFR) is a key regulator of pattern formation and morphogenesis in Drosophila oogenesis. EGFR signalling in oogenesis can be genetically manipulated and monitored at many levels, leading to large sets of heterogeneous data that enable the formulation of increasingly quantitative models of pattern formation in these systems.

Original languageEnglish (US)
Pages (from-to)276-284
Number of pages9
JournalIEE Proceedings Systems Biology
Issue number4
StatePublished - Dec 2005

All Science Journal Classification (ASJC) codes

  • Genetics
  • Molecular Medicine
  • Molecular Biology
  • Biotechnology
  • Cell Biology
  • Modeling and Simulation


  • Biochemistry
  • Biological tissues
  • Cell fate diversification
  • Cellular biophysics
  • Developing tissues
  • Drosophila egg development
  • Drosophila oogenesis
  • Enzymes
  • Epidermal growth factor receptor
  • Genetic manipulation
  • Genetics
  • Molecular biophysics
  • Pattern formation
  • Physiological models


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