Systems biology of bacterial chemotaxis

Melinda D. Baker, Peter M. Wolanin, Jeffry B. Stock

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Motile bacteria regulate chemotaxis through a highly conserved chemosensory signal-transduction system. System-wide analyses and mathematical modeling are facilitated by extensive experimental observations regarding bacterial chemotaxis proteins, including biochemical parameters, protein structures and protein-protein interaction maps. Thousands of signaling and regulatory chemotaxis proteins within a bacteria cell form a highly interconnected network through distinct protein-protein interactions. A bacterial cell is able to respond to multiple stimuli through a collection of chemoreceptors with different sensory modalities, which interact to affect the cooperativity and sensitivity of the chemotaxis response. The robustness or insensitivity of the chemotaxis system to perturbations in biochemical parameters is a product of the system's hierarchical network architecture.

Original languageEnglish (US)
Pages (from-to)187-192
Number of pages6
JournalCurrent opinion in microbiology
Issue number2
StatePublished - Apr 2006

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases
  • Microbiology


Dive into the research topics of 'Systems biology of bacterial chemotaxis'. Together they form a unique fingerprint.

Cite this