Synthetic fluorescent sensors for studying the cell biology of metals

Dylan W. Domaille; Emily L. Que; Christopher J. Chang

doi:10.1038/nchembio.69

Synthetic fluorescent sensors for studying the cell biology of metals

Dylan W. Domaille, Emily L. Que, Christopher J. Chang

Research output: Contribution to journal › Review article › peer-review

1022 Scopus citations

Abstract

Metals are essential for sustaining all forms of life, but alterations in their cellular homeostasis are connected to severe human disorders, including cancer, diabetes and neurodegenerative diseases. Fluorescent small molecules that respond to metal ions in the cell with appropriate selectivity and sensitivity offer the ability to probe physiological and pathological consequences of the cell biology of metals with spatial and temporal fidelity. Molecular imaging of normal and abnormal cellular metal ion pools using these new chemical tools provides a host of emerging opportunities for visualizing, in real time, aspects of metal accumulation, trafficking, and function or toxicity in living systems. This review presents a brief survey of available synthetic small-molecule sensor types for fluorescence detection of cellular metals.

Original language	English (US)
Pages (from-to)	168-175
Number of pages	8
Journal	Nature Chemical Biology
Volume	4
Issue number	3
DOIs	https://doi.org/10.1038/nchembio.69
State	Published - Mar 2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1038/nchembio.69

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Synthetic fluorescent sensors for studying the cell biology of metals

Abstract

All Science Journal Classification (ASJC) codes

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