Synthetic approaches to thienamycin: Carbon-carbon bond formation at C-4 of azetidin-2-ones

Paul J. Reider; Richard Rayford; Edward J.J. Grabowski

doi:10.1016/S0040-4039(00)86836-7

Synthetic approaches to thienamycin: Carbon-carbon bond formation at C-4 of azetidin-2-ones

Paul J. Reider
, Richard Rayford
, Edward J.J. Grabowski

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A mild and efficient method of β-lactam alkylation has been achieved using 4-acetoxy-2-azetidinone and a variety of silyl enol ethers.

Original language	English (US)
Pages (from-to)	379-382
Number of pages	4
Journal	Tetrahedron Letters
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/S0040-4039(00)86836-7
State	Published - 1982
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)86836-7

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title = "Synthetic approaches to thienamycin: Carbon-carbon bond formation at C-4 of azetidin-2-ones",

abstract = "A mild and efficient method of β-lactam alkylation has been achieved using 4-acetoxy-2-azetidinone and a variety of silyl enol ethers.",

author = "Reider, \{Paul J.\} and Richard Rayford and Grabowski, \{Edward J.J.\}",

year = "1982",

doi = "10.1016/S0040-4039(00)86836-7",

language = "English (US)",

volume = "23",

pages = "379--382",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

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T1 - Synthetic approaches to thienamycin

T2 - Carbon-carbon bond formation at C-4 of azetidin-2-ones

AU - Reider, Paul J.

AU - Rayford, Richard

AU - Grabowski, Edward J.J.

PY - 1982

Y1 - 1982

N2 - A mild and efficient method of β-lactam alkylation has been achieved using 4-acetoxy-2-azetidinone and a variety of silyl enol ethers.

AB - A mild and efficient method of β-lactam alkylation has been achieved using 4-acetoxy-2-azetidinone and a variety of silyl enol ethers.

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UR - https://www.scopus.com/pages/publications/0020036681#tab=citedBy

U2 - 10.1016/S0040-4039(00)86836-7

DO - 10.1016/S0040-4039(00)86836-7

M3 - Article

AN - SCOPUS:0020036681

SN - 0040-4039

VL - 23

SP - 379

EP - 382

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 4

ER -

Synthetic approaches to thienamycin: Carbon-carbon bond formation at C-4 of azetidin-2-ones

Abstract

All Science Journal Classification (ASJC) codes

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