Synthetic approaches to thienamycin: Carbon-carbon bond formation at C-4 of azetidin-2-ones

Paul J. Reider, Richard Rayford, Edward J.J. Grabowski

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

A mild and efficient method of β-lactam alkylation has been achieved using 4-acetoxy-2-azetidinone and a variety of silyl enol ethers.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalTetrahedron Letters
Volume23
Issue number4
DOIs
StatePublished - 1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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