Synthesis of the furanosteroidal antibiotic viridin

Edward A. Anderson, Erik J. Alexanian, Erik J. Sorensen

Research output: Contribution to journalArticlepeer-review

91 Scopus citations

Abstract

A rhodium-catalyzed alkyne cyclotrimerization, domino electrocyclic reactions, and a hydroxy-directed dihydroxylation are key steps in an efficient synthesis of the bioactive furanosteroid viridin (1) from a simple acyclic triyne.

Original languageEnglish (US)
Pages (from-to)1998-2001
Number of pages4
JournalAngewandte Chemie - International Edition
Volume43
Issue number15
DOIs
StatePublished - Apr 2 2004

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Keywords

  • Cyclotrimerization
  • Dihydroxylation
  • Electrocyclic reactions
  • Inhibitors
  • Natural products

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