Synthesis of the furanosteroidal antibiotic viridin

Edward A. Anderson; Erik J. Alexanian; Erik J. Sorensen

doi:10.1002/anie.200353129

Synthesis of the furanosteroidal antibiotic viridin

Edward A. Anderson, Erik J. Alexanian, Erik J. Sorensen

Chemistry

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

A rhodium-catalyzed alkyne cyclotrimerization, domino electrocyclic reactions, and a hydroxy-directed dihydroxylation are key steps in an efficient synthesis of the bioactive furanosteroid viridin (1) from a simple acyclic triyne.

Original language	English (US)
Pages (from-to)	1998-2001
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	15
DOIs	https://doi.org/10.1002/anie.200353129
State	Published - Apr 2 2004

All Science Journal Classification (ASJC) codes

General Chemistry
Catalysis

Keywords

Cyclotrimerization
Dihydroxylation
Electrocyclic reactions
Inhibitors
Natural products

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10.1002/anie.200353129

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title = "Synthesis of the furanosteroidal antibiotic viridin",

abstract = "A rhodium-catalyzed alkyne cyclotrimerization, domino electrocyclic reactions, and a hydroxy-directed dihydroxylation are key steps in an efficient synthesis of the bioactive furanosteroid viridin (1) from a simple acyclic triyne.",

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author = "Anderson, {Edward A.} and Alexanian, {Erik J.} and Sorensen, {Erik J.}",

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AU - Alexanian, Erik J.

AU - Sorensen, Erik J.

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KW - Dihydroxylation

KW - Electrocyclic reactions

KW - Inhibitors

KW - Natural products

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Synthesis of the furanosteroidal antibiotic viridin

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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