Synthesis of the functionalizable methionine surrogate azidohomoalanine using Boc-homoserine as precursor

A. James Link; Mandy K.S. Vink; David A. Tirrell

doi:10.1038/nprot.2007.269

Synthesis of the functionalizable methionine surrogate azidohomoalanine using Boc-homoserine as precursor

A. James Link, Mandy K.S. Vink, David A. Tirrell

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10 Scopus citations

Abstract

This protocol describes a synthetic route to the non-canonical amino acid azidohomoalanine (AHA) using protected homoserine as a starting material. An alternative route to AHA is presented in a companion paper. This synthesis can be completed in 5 days.

Original language	English (US)
Pages (from-to)	1884-1887
Number of pages	4
Journal	Nature Protocols
Volume	2
Issue number	8
DOIs	https://doi.org/10.1038/nprot.2007.269
State	Published - Aug 2007

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1038/nprot.2007.269

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title = "Synthesis of the functionalizable methionine surrogate azidohomoalanine using Boc-homoserine as precursor",

abstract = "This protocol describes a synthetic route to the non-canonical amino acid azidohomoalanine (AHA) using protected homoserine as a starting material. An alternative route to AHA is presented in a companion paper. This synthesis can be completed in 5 days.",

author = "Link, {A. James} and Vink, {Mandy K.S.} and Tirrell, {David A.}",

note = "Funding Information: ACKNOWLEDGMENTS This work was supported by NIH, by an NSF graduate fellowship to A.J.L. and by a grant from the Netherlands Organization for Scientific Research to M.K.S.V.",

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Synthesis of the functionalizable methionine surrogate azidohomoalanine using Boc-homoserine as precursor

Abstract

All Science Journal Classification (ASJC) codes

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