Synthesis of the 5-HT1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction

Cheng yi Chen; David R. Lieberman; Robert D. Larsen; Robert A. Reamer; Thomas R. Verhoeven; Paul J. Reider; Ian F. Cottrell; Peter G. Houghton

doi:10.1016/0040-4039(94)88204-5

Synthesis of the 5-HT_1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction

Cheng yi Chen, David R. Lieberman, Robert D. Larsen, Robert A. Reamer, Thomas R. Verhoeven, Paul J. Reider, Ian F. Cottrell, Peter G. Houghton

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

Abstract

Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT_1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.

Original language	English (US)
Pages (from-to)	6981-6984
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	38
DOIs	https://doi.org/10.1016/0040-4039(94)88204-5
State	Published - Sep 19 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(94)88204-5

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title = "Synthesis of the 5-HT1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction",

abstract = "Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.",

author = "Chen, {Cheng yi} and Lieberman, {David R.} and Larsen, {Robert D.} and Reamer, {Robert A.} and Verhoeven, {Thomas R.} and Reider, {Paul J.} and Cottrell, {Ian F.} and Houghton, {Peter G.}",

year = "1994",

month = sep,

day = "19",

doi = "10.1016/0040-4039(94)88204-5",

language = "English (US)",

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journal = "Tetrahedron Letters",

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T1 - Synthesis of the 5-HT1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction

AU - Chen, Cheng yi

AU - Lieberman, David R.

AU - Larsen, Robert D.

AU - Reamer, Robert A.

AU - Verhoeven, Thomas R.

AU - Reider, Paul J.

AU - Cottrell, Ian F.

AU - Houghton, Peter G.

PY - 1994/9/19

Y1 - 1994/9/19

N2 - Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.

AB - Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.

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U2 - 10.1016/0040-4039(94)88204-5

DO - 10.1016/0040-4039(94)88204-5

M3 - Article

AN - SCOPUS:0028024461

SN - 0040-4039

VL - 35

SP - 6981

EP - 6984

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 38

ER -

Synthesis of the 5-HT_1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction

Abstract

All Science Journal Classification (ASJC) codes

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