Synthesis of the 5-HT1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction

Cheng yi Chen, David R. Lieberman, Robert D. Larsen, Robert A. Reamer, Thomas R. Verhoeven, Paul J. Reider, Ian F. Cottrell, Peter G. Houghton

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Abstract

Application of a palladium-catalyzed coupling between 3 and 5a to the synthesis of the novel 5-HT1D receptor agonist MK-0462 (1), a potential anti-migraine drug, is described.

Original languageEnglish (US)
Pages (from-to)6981-6984
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number38
DOIs
StatePublished - Sep 19 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Chen, C. Y., Lieberman, D. R., Larsen, R. D., Reamer, R. A., Verhoeven, T. R., Reider, P. J., Cottrell, I. F., & Houghton, P. G. (1994). Synthesis of the 5-HT1D receptor agonist MK-0462 via a Pd-catalyzed coupling reaction. Tetrahedron Letters, 35(38), 6981-6984. https://doi.org/10.1016/0040-4039(94)88204-5