Synthesis of Seleno-Toluidine Blue

John T. Groves; S. Martin Lindenauer; Jerome S. Schultz

doi:10.1021/jm00254a027

Synthesis of Seleno-Toluidine Blue

John T. Groves
, S. Martin Lindenauer
, Jerome S. Schultz

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Toluidine blue has been shown to have high specificity for the parathyroid, pancreas, and heart and has been useful in identifying parathyroid tissue at operation.¹ ³⁵S-Toluidine blue shows a similar distributional pattern² but since ³5S is an α-emitting isotope this compound is not efficient for scintiscanning. We report here an efficient synthesis of seleno-toluidine blue (1) by a procedure suitable for the incorporation of ⁷⁵Se, a γ-emitting isotope with a convenient half-life (121 days). This compound has physical and biological properties similar to those of toluidine blue and is thus an attractive candidate for diagnostic scintiscanning techniques³.

Original language	English (US)
Pages (from-to)	902-904
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	17
Issue number	8
DOIs	https://doi.org/10.1021/jm00254a027
State	Published - Aug 1 1974
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery

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10.1021/jm00254a027

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@article{496d3ed72635465bbe8d582b31475a84,

title = "Synthesis of Seleno-Toluidine Blue",

abstract = "Toluidine blue has been shown to have high specificity for the parathyroid, pancreas, and heart and has been useful in identifying parathyroid tissue at operation.1 35S-Toluidine blue shows a similar distributional pattern2 but since 35S is an α-emitting isotope this compound is not efficient for scintiscanning. We report here an efficient synthesis of seleno-toluidine blue (1) by a procedure suitable for the incorporation of 75Se, a γ-emitting isotope with a convenient half-life (121 days). This compound has physical and biological properties similar to those of toluidine blue and is thus an attractive candidate for diagnostic scintiscanning techniques3.",

author = "Groves, \{John T.\} and Lindenauer, \{S. Martin\} and Schultz, \{Jerome S.\}",

year = "1974",

month = aug,

day = "1",

doi = "10.1021/jm00254a027",

language = "English (US)",

volume = "17",

pages = "902--904",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Synthesis of Seleno-Toluidine Blue

AU - Groves, John T.

AU - Lindenauer, S. Martin

AU - Schultz, Jerome S.

PY - 1974/8/1

Y1 - 1974/8/1

N2 - Toluidine blue has been shown to have high specificity for the parathyroid, pancreas, and heart and has been useful in identifying parathyroid tissue at operation.1 35S-Toluidine blue shows a similar distributional pattern2 but since 35S is an α-emitting isotope this compound is not efficient for scintiscanning. We report here an efficient synthesis of seleno-toluidine blue (1) by a procedure suitable for the incorporation of 75Se, a γ-emitting isotope with a convenient half-life (121 days). This compound has physical and biological properties similar to those of toluidine blue and is thus an attractive candidate for diagnostic scintiscanning techniques3.

AB - Toluidine blue has been shown to have high specificity for the parathyroid, pancreas, and heart and has been useful in identifying parathyroid tissue at operation.1 35S-Toluidine blue shows a similar distributional pattern2 but since 35S is an α-emitting isotope this compound is not efficient for scintiscanning. We report here an efficient synthesis of seleno-toluidine blue (1) by a procedure suitable for the incorporation of 75Se, a γ-emitting isotope with a convenient half-life (121 days). This compound has physical and biological properties similar to those of toluidine blue and is thus an attractive candidate for diagnostic scintiscanning techniques3.

UR - https://www.scopus.com/pages/publications/0016255493

UR - https://www.scopus.com/pages/publications/0016255493#tab=citedBy

U2 - 10.1021/jm00254a027

DO - 10.1021/jm00254a027

M3 - Article

C2 - 4845385

AN - SCOPUS:0016255493

SN - 0022-2623

VL - 17

SP - 902

EP - 904

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 8

ER -

Synthesis of Seleno-Toluidine Blue

Abstract

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