Synthesis of Seleno-Toluidine Blue

John T. Groves, S. Martin Lindenauer, Jerome S. Schultz

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Toluidine blue has been shown to have high specificity for the parathyroid, pancreas, and heart and has been useful in identifying parathyroid tissue at operation.1 35S-Toluidine blue shows a similar distributional pattern2 but since 35S is an α-emitting isotope this compound is not efficient for scintiscanning. We report here an efficient synthesis of seleno-toluidine blue (1) by a procedure suitable for the incorporation of 75Se, a γ-emitting isotope with a convenient half-life (121 days). This compound has physical and biological properties similar to those of toluidine blue and is thus an attractive candidate for diagnostic scintiscanning techniques3.

Original languageEnglish (US)
Pages (from-to)902-904
Number of pages3
JournalJournal of Medicinal Chemistry
Issue number8
StatePublished - Aug 1 1974
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Molecular Medicine


Dive into the research topics of 'Synthesis of Seleno-Toluidine Blue'. Together they form a unique fingerprint.

Cite this