Toluidine blue has been shown to have high specificity for the parathyroid, pancreas, and heart and has been useful in identifying parathyroid tissue at operation.1 35S-Toluidine blue shows a similar distributional pattern2 but since 35S is an α-emitting isotope this compound is not efficient for scintiscanning. We report here an efficient synthesis of seleno-toluidine blue (1) by a procedure suitable for the incorporation of 75Se, a γ-emitting isotope with a convenient half-life (121 days). This compound has physical and biological properties similar to those of toluidine blue and is thus an attractive candidate for diagnostic scintiscanning techniques3.
All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Drug Discovery