Synthesis of iron-binding oligonucleotides and their reactions with single-stranded DNA

Ismail O. Kady; John Taylor Groves

doi:10.1016/S0960-894X(00)80350-9

Synthesis of iron-binding oligonucleotides and their reactions with single-stranded DNA

Ismail O. Kady, John Taylor Groves

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Two 12-base oligonucleotides were synthesized and modified by attaching metal-binding ligands (2,6-pyridinedicarboxylate and 2,2′-dipicolylamine) to their 5′-ends. When hybridized to a 135-base single stranded DNA, in the presence of Fe²⁺, O₂, and a reducing agent, these obligonucleotides cleaved the complementary DNA chain with unique and high base-sequence specificities.

Original language	English (US)
Pages (from-to)	1367-1370
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(00)80350-9
State	Published - Jan 1 1993

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)80350-9

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abstract = "Two 12-base oligonucleotides were synthesized and modified by attaching metal-binding ligands (2,6-pyridinedicarboxylate and 2,2′-dipicolylamine) to their 5′-ends. When hybridized to a 135-base single stranded DNA, in the presence of Fe2+, O2, and a reducing agent, these obligonucleotides cleaved the complementary DNA chain with unique and high base-sequence specificities.",

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AU - Groves, John Taylor

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AB - Two 12-base oligonucleotides were synthesized and modified by attaching metal-binding ligands (2,6-pyridinedicarboxylate and 2,2′-dipicolylamine) to their 5′-ends. When hybridized to a 135-base single stranded DNA, in the presence of Fe2+, O2, and a reducing agent, these obligonucleotides cleaved the complementary DNA chain with unique and high base-sequence specificities.

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Synthesis of iron-binding oligonucleotides and their reactions with single-stranded DNA

Abstract

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