Synthesis of iron-binding oligonucleotides and their reactions with single-stranded DNA

Ismail O. Kady, John Taylor Groves

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Two 12-base oligonucleotides were synthesized and modified by attaching metal-binding ligands (2,6-pyridinedicarboxylate and 2,2′-dipicolylamine) to their 5′-ends. When hybridized to a 135-base single stranded DNA, in the presence of Fe2+, O2, and a reducing agent, these obligonucleotides cleaved the complementary DNA chain with unique and high base-sequence specificities.

Original languageEnglish (US)
Pages (from-to)1367-1370
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number6
DOIs
StatePublished - Jan 1 1993

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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