Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394

Ioannis N. Houpis; W. B. Choi; P. J. Reider; Audrey Molina; Hywyn Churchill; Joseph Lynch; R. P. Volante

doi:10.1016/S0040-4039(00)78541-8

Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394

Ioannis N. Houpis
, W. B. Choi
, P. J. Reider
, Audrey Molina
, Hywyn Churchill
, Joseph Lynch
, R. P. Volante

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

The synthesis of 1 was accomplished in 55% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.

Original language	English (US)
Pages (from-to)	9355-9358
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	50
DOIs	https://doi.org/10.1016/S0040-4039(00)78541-8
State	Published - Dec 12 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)78541-8

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Houpis, I. N., Choi, W. B., Reider, P. J., Molina, A., Churchill, H., Lynch, J., & Volante, R. P. (1994). Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394. Tetrahedron Letters, 35(50), 9355-9358. https://doi.org/10.1016/S0040-4039(00)78541-8

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title = "Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394",

abstract = "The synthesis of 1 was accomplished in 55\% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.",

author = "Houpis, \{Ioannis N.\} and Choi, \{W. B.\} and Reider, \{P. J.\} and Audrey Molina and Hywyn Churchill and Joseph Lynch and Volante, \{R. P.\}",

year = "1994",

month = dec,

day = "12",

doi = "10.1016/S0040-4039(00)78541-8",

language = "English (US)",

volume = "35",

pages = "9355--9358",

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Houpis, IN, Choi, WB, Reider, PJ, Molina, A, Churchill, H, Lynch, J & Volante, RP 1994, 'Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394', Tetrahedron Letters, vol. 35, no. 50, pp. 9355-9358. https://doi.org/10.1016/S0040-4039(00)78541-8

Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394. / Houpis, Ioannis N.; Choi, W. B.; Reider, P. J. et al.
In: Tetrahedron Letters, Vol. 35, No. 50, 12.12.1994, p. 9355-9358.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394

AU - Houpis, Ioannis N.

AU - Choi, W. B.

AU - Reider, P. J.

AU - Molina, Audrey

AU - Churchill, Hywyn

AU - Lynch, Joseph

AU - Volante, R. P.

PY - 1994/12/12

Y1 - 1994/12/12

N2 - The synthesis of 1 was accomplished in 55% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.

AB - The synthesis of 1 was accomplished in 55% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.

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DO - 10.1016/S0040-4039(00)78541-8

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VL - 35

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JO - Tetrahedron Letters

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ER -

Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394

Abstract

All Science Journal Classification (ASJC) codes

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