Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394

Ioannis N. Houpis, W. B. Choi, P. J. Reider, Audrey Molina, Hywyn Churchill, Joseph Lynch, R. P. Volante

Research output: Contribution to journalArticlepeer-review

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Abstract

The synthesis of 1 was accomplished in 55% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.

Original languageEnglish (US)
Pages (from-to)9355-9358
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number50
DOIs
StatePublished - Dec 12 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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