Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394

Ioannis N. Houpis; W. B. Choi; P. J. Reider; Audrey Molina; Hywyn Churchill; Joseph Lynch; R. P. Volante

doi:10.1016/S0040-4039(00)78541-8

Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394

Ioannis N. Houpis, W. B. Choi, P. J. Reider, Audrey Molina, Hywyn Churchill, Joseph Lynch, R. P. Volante

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

The synthesis of 1 was accomplished in 55% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.

Original language	English (US)
Pages (from-to)	9355-9358
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	50
DOIs	https://doi.org/10.1016/S0040-4039(00)78541-8
State	Published - Dec 12 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)78541-8

Cite this

Houpis, I. N., Choi, W. B., Reider, P. J., Molina, A., Churchill, H., Lynch, J., & Volante, R. P. (1994). Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394. Tetrahedron Letters, 35(50), 9355-9358. https://doi.org/10.1016/S0040-4039(00)78541-8

@article{4d73aaf49b8f4616816db8541fe9759f,

title = "Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394",

abstract = "The synthesis of 1 was accomplished in 55% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.",

author = "Houpis, {Ioannis N.} and Choi, {W. B.} and Reider, {P. J.} and Audrey Molina and Hywyn Churchill and Joseph Lynch and Volante, {R. P.}",

year = "1994",

month = dec,

day = "12",

doi = "10.1016/S0040-4039(00)78541-8",

language = "English (US)",

volume = "35",

pages = "9355--9358",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "50",

}

Houpis, IN, Choi, WB, Reider, PJ, Molina, A, Churchill, H, Lynch, J & Volante, RP 1994, 'Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394', Tetrahedron Letters, vol. 35, no. 50, pp. 9355-9358. https://doi.org/10.1016/S0040-4039(00)78541-8

Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394. / Houpis, Ioannis N.; Choi, W. B.; Reider, P. J. et al.

In: Tetrahedron Letters, Vol. 35, No. 50, 12.12.1994, p. 9355-9358.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394

AU - Houpis, Ioannis N.

AU - Choi, W. B.

AU - Reider, P. J.

AU - Molina, Audrey

AU - Churchill, Hywyn

AU - Lynch, Joseph

AU - Volante, R. P.

PY - 1994/12/12

Y1 - 1994/12/12

N2 - The synthesis of 1 was accomplished in 55% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.

AB - The synthesis of 1 was accomplished in 55% overall yield via the Pd-catalyzed coupling of 3 and 4 followed by Cu-catalyzed cyclization of the resulting intermediate 2.

UR - http://www.scopus.com/inward/record.url?scp=0027971183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027971183&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)78541-8

DO - 10.1016/S0040-4039(00)78541-8

M3 - Article

AN - SCOPUS:0027971183

SN - 0040-4039

VL - 35

SP - 9355

EP - 9358

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 50

ER -

Synthesis of functionalized furo[2,3-b]pyridines via the Pd-catalyzed coupling of acetylenes to iodopyridones. Preparation of a key intermediate to a new HIV protease inhibitor L-754,394

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this