@article{dbad559aaa2647b4af6919ee3af4c431,
title = "Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis",
abstract = "We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl halides to produce artificial analogues of phenylalanine, tryptophan, and histidine. The reaction is tolerant of a broad range of functionalities and can be leveraged toward the scalable synthesis of valuable pharmaceutical scaffolds via flow technology.",
keywords = "flow chemistry, heterocycles, nickel catalysis, photoredox catalysis, unnatural amino acids",
author = "Faraggi, {Tomer M.} and Caroline Rouget-Virbel and Rinc{\'o}n, {Juan A.} and Mario Barberis and Carlos Mateos and Susana Garc{\'i}a-Cerrada and Javier Agejas and {De Frutos}, Oscar and Macmillan, {David W.C.}",
note = "Funding Information: The authors are grateful for financial support provided by the National Institute of General Medical Sciences (NIGMS), the NIH (under Award R35GM134897-01), the Princeton Catalysis Initiative, and kind gifts from Eli Lilly, Merck, Janssen, BMS, Genentech, Celgene, and Pfizer. T.M.F. acknowledges Princeton University, E. Taylor, and the Taylor family for an Edward C. Taylor Fellowship. This work was supported by Eli Lilly and Company through the Lilly Research Award Program (LRAP). Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",
year = "2021",
month = aug,
day = "20",
doi = "10.1021/acs.oprd.1c00208",
language = "English (US)",
volume = "25",
pages = "1966--1973",
journal = "Organic Process Research and Development",
issn = "1083-6160",
publisher = "American Chemical Society",
number = "8",
}