Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD4Antagonist

D. L. Hughes; J. J. Bergan; J. S. Amato; P. J. Reider; E. J.E. Grabowski

doi:10.1021/jo00269a007

Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD₄Antagonist

D. L. Hughes, J. J. Bergan, J. S. Amato, P. J. Reider, E. J.E. Grabowski

Research output: Contribution to journal › Letter › peer-review

35 Scopus citations

Abstract

An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD₄antagonist, MK-0571.

Original language	English (US)
Pages (from-to)	1787-1788
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	54
Issue number	8
DOIs	https://doi.org/10.1021/jo00269a007
State	Published - Apr 1 1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/jo00269a007

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title = "Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD4Antagonist",

abstract = "An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD4antagonist, MK-0571.",

author = "Hughes, \{D. L.\} and Bergan, \{J. J.\} and Amato, \{J. S.\} and Reider, \{P. J.\} and Grabowski, \{E. J.E.\}",

year = "1989",

month = apr,

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doi = "10.1021/jo00269a007",

language = "English (US)",

volume = "54",

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journal = "Journal of Organic Chemistry",

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publisher = "American Chemical Society",

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T1 - Synthesis of Chiral Dithioacetals

T2 - A Chemoenzymic Synthesis of a Novel LTD4Antagonist

AU - Hughes, D. L.

AU - Bergan, J. J.

AU - Amato, J. S.

AU - Reider, P. J.

AU - Grabowski, E. J.E.

PY - 1989/4/1

Y1 - 1989/4/1

N2 - An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD4antagonist, MK-0571.

AB - An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD4antagonist, MK-0571.

UR - https://www.scopus.com/pages/publications/0024501828

UR - https://www.scopus.com/inward/citedby.url?scp=0024501828&partnerID=8YFLogxK

U2 - 10.1021/jo00269a007

DO - 10.1021/jo00269a007

M3 - Letter

AN - SCOPUS:0024501828

SN - 0022-3263

VL - 54

SP - 1787

EP - 1788

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 8

ER -

Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD₄Antagonist

Abstract

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