Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD4Antagonist

D. L. Hughes; J. J. Bergan; J. S. Amato; P. J. Reider; E. J.E. Grabowski

doi:10.1021/jo00269a007

Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD₄Antagonist

D. L. Hughes, J. J. Bergan, J. S. Amato, P. J. Reider, E. J.E. Grabowski

Research output: Contribution to journal › Letter › peer-review

31 Scopus citations

Abstract

An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD₄antagonist, MK-0571.

Original language	English (US)
Pages (from-to)	1787-1788
Number of pages	2
Journal	Journal of Organic Chemistry
Volume	54
Issue number	8
DOIs	https://doi.org/10.1021/jo00269a007
State	Published - Apr 1 1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Organic Chemistry

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10.1021/jo00269a007

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title = "Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD4Antagonist",

abstract = "An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD4antagonist, MK-0571.",

author = "Hughes, {D. L.} and Bergan, {J. J.} and Amato, {J. S.} and Reider, {P. J.} and Grabowski, {E. J.E.}",

year = "1989",

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language = "English (US)",

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T1 - Synthesis of Chiral Dithioacetals

T2 - A Chemoenzymic Synthesis of a Novel LTD4Antagonist

AU - Hughes, D. L.

AU - Bergan, J. J.

AU - Amato, J. S.

AU - Reider, P. J.

AU - Grabowski, E. J.E.

PY - 1989/4/1

Y1 - 1989/4/1

N2 - An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD4antagonist, MK-0571.

AB - An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD4antagonist, MK-0571.

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M3 - Letter

AN - SCOPUS:0024501828

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD₄Antagonist

Abstract

All Science Journal Classification (ASJC) codes

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