Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD4Antagonist

D. L. Hughes, J. J. Bergan, J. S. Amato, P. J. Reider, E. J.E. Grabowski

Research output: Contribution to journalLetterpeer-review

29 Scopus citations

Abstract

An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD4antagonist, MK-0571.

Original languageEnglish (US)
Pages (from-to)1787-1788
Number of pages2
JournalJournal of Organic Chemistry
Volume54
Issue number8
DOIs
StatePublished - Apr 1 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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