Synthesis of Chiral Dithioacetals: A Chemoenzymic Synthesis of a Novel LTD4Antagonist

D. L. Hughes, J. J. Bergan, J. S. Amato, P. J. Reider, E. J.E. Grabowski

Research output: Contribution to journalLetter

29 Scopus citations

Abstract

An enantioselective enzymatic hydrolysis of prochiral diester 3, having four bonds between the prochiral center and ester group, serves as the key step in a short and efficient synthesis of both enantiomers of the selective LTD4antagonist, MK-0571.

Original languageEnglish (US)
Pages (from-to)1787-1788
Number of pages2
JournalJournal of Organic Chemistry
Volume54
Issue number8
DOIs
StatePublished - Apr 1 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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