Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912: An O-analogue of the Pictet-Spengler reaction

J. Albaneze-Walker; K. Rossen; R. A. Reamer; R. P. Volante; P. J. Reider

doi:10.1016/S0040-4039(99)00840-0

Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912: An O-analogue of the Pictet-Spengler reaction

J. Albaneze-Walker, K. Rossen, R. A. Reamer, R. P. Volante, P. J. Reider

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet- Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.

Original language	English (US)
Pages (from-to)	4917-4920
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	27
DOIs	https://doi.org/10.1016/S0040-4039(99)00840-0
State	Published - Jul 2 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(99)00840-0

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title = "Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912: An O-analogue of the Pictet-Spengler reaction",

abstract = "Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet- Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.",

author = "J. Albaneze-Walker and K. Rossen and Reamer, {R. A.} and Volante, {R. P.} and Reider, {P. J.}",

year = "1999",

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doi = "10.1016/S0040-4039(99)00840-0",

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T1 - Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912

T2 - An O-analogue of the Pictet-Spengler reaction

AU - Albaneze-Walker, J.

AU - Rossen, K.

AU - Reamer, R. A.

AU - Volante, R. P.

AU - Reider, P. J.

PY - 1999/7/2

Y1 - 1999/7/2

N2 - Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet- Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.

AB - Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet- Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.

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U2 - 10.1016/S0040-4039(99)00840-0

DO - 10.1016/S0040-4039(99)00840-0

M3 - Article

AN - SCOPUS:0033516717

SN - 0040-4039

VL - 40

SP - 4917

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 27

ER -

Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912: An O-analogue of the Pictet-Spengler reaction

Abstract

All Science Journal Classification (ASJC) codes

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