Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912: An O-analogue of the Pictet-Spengler reaction

J. Albaneze-Walker, K. Rossen, R. A. Reamer, R. P. Volante, P. J. Reider

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet- Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.

Original languageEnglish (US)
Pages (from-to)4917-4920
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number27
DOIs
StatePublished - Jul 2 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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