Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated stille coupling

Mark S. Jensen, Chunhua Yang, Yi Hsiao, Nelo Rivera, Kenneth M. Wells, John Y.L. Chung, Nobuyoshi Yasuda, David L. Hughes, Paul J. Reider

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

A short synthesis of carbapenem 1 is described. The key step involves the cross-coupling of an enol triflate with an amino-substituted sp3 carbon. This cross-couping, which allows the introduction of the complete side chain in one step, utilizes a stannatrane as the heteroalkyl transfer reagent.

Original languageEnglish (US)
Pages (from-to)1081-1083
Number of pages3
JournalOrganic letters
Volume2
Issue number8
DOIs
StatePublished - Apr 20 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated stille coupling'. Together they form a unique fingerprint.

Cite this