Synthesis of a new generation reverse transcriptase inhibitor via the BCl3/GaCl3-induced condensation of anilines with nitriles (sugasawa reaction)

Ioannis N. Houpis; Audrey Molina; Alan W. Douglas; Lyndon Xavier; Joseph Lynch; R. P. Volante; P. J. Reider

doi:10.1016/0040-4039(94)85011-9

Synthesis of a new generation reverse transcriptase inhibitor via the BCl₃/GaCl₃-induced condensation of anilines with nitriles (sugasawa reaction)

Ioannis N. Houpis, Audrey Molina, Alan W. Douglas, Lyndon Xavier, Joseph Lynch, R. P. Volante, P. J. Reider

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.

Original language	English (US)
Pages (from-to)	6811-6814
Number of pages	4
Journal	Tetrahedron Letters
Volume	35
Issue number	37
DOIs	https://doi.org/10.1016/0040-4039(94)85011-9
State	Published - Sep 12 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(94)85011-9

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title = "Synthesis of a new generation reverse transcriptase inhibitor via the BCl3/GaCl3-induced condensation of anilines with nitriles (sugasawa reaction)",

abstract = "The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.",

author = "Houpis, {Ioannis N.} and Audrey Molina and Douglas, {Alan W.} and Lyndon Xavier and Joseph Lynch and Volante, {R. P.} and Reider, {P. J.}",

year = "1994",

month = sep,

day = "12",

doi = "10.1016/0040-4039(94)85011-9",

language = "English (US)",

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journal = "Tetrahedron Letters",

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T1 - Synthesis of a new generation reverse transcriptase inhibitor via the BCl3/GaCl3-induced condensation of anilines with nitriles (sugasawa reaction)

AU - Houpis, Ioannis N.

AU - Molina, Audrey

AU - Douglas, Alan W.

AU - Xavier, Lyndon

AU - Lynch, Joseph

AU - Volante, R. P.

AU - Reider, P. J.

PY - 1994/9/12

Y1 - 1994/9/12

N2 - The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.

AB - The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.

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U2 - 10.1016/0040-4039(94)85011-9

DO - 10.1016/0040-4039(94)85011-9

M3 - Article

AN - SCOPUS:0027981374

SN - 0040-4039

VL - 35

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EP - 6814

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 37

ER -

Synthesis of a new generation reverse transcriptase inhibitor via the BCl₃/GaCl₃-induced condensation of anilines with nitriles (sugasawa reaction)

Abstract

All Science Journal Classification (ASJC) codes

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