Synthesis of a new generation reverse transcriptase inhibitor via the BCl3/GaCl3-induced condensation of anilines with nitriles (sugasawa reaction)

Ioannis N. Houpis, Audrey Molina, Alan W. Douglas, Lyndon Xavier, Joseph Lynch, R. P. Volante, P. J. Reider

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The synthesis of 1 was achieved in high overall yield through a mechanism-based improvement of the preparation of o-acyl anilines.

Original languageEnglish (US)
Pages (from-to)6811-6814
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number37
DOIs
StatePublished - Sep 12 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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