Abstract
Quaternary carbons are useful motifs in chemical synthesis but can be challenging to prepare using many chemical methods. Here, we report a stereoselective synthesis of β-quaternary lactams using flavin-dependent ‘ene’-reductases via a 5-exo-trig radical cyclization. The products are formed in moderate to good levels of enantioselectivity using an ‘ene’-reductase variant from Zymomonas mobilis. This method highlights the opportunity for biocatalysis to form quaternary centers using non-natural reactions.
Original language | English (US) |
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Article number | e202300274 |
Journal | Asian Journal of Organic Chemistry |
Volume | 12 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2023 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Organic Chemistry
Keywords
- Biocatalysis
- Directed Evolution
- Photoenzyme
- Proteins and Peptides
- Quaternary Carbons