Synthesis and pharmacological activity of 1‐(arylsulfonyl)‐3,5‐dialkyl‐s‐triazine‐2,4,6‐(1H, 3H,5H)‐triones

George N. Holcomb, Lorraine A. Klemm, Thomas J. Silhavy, Raymond E. Counsell

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A series of five 1‐(arylsulfonyl)‐3,5‐dialkyl‐s‐triazine‐2,4,6‐(1H,3H,5H)‐triones was synthesized by the base‐catalyzed reaction of arylsulfonamides with alkyl isocyanates. The compounds were tested for apomorphine antagonism in mice, diuretic activity in fasted rats, antiviral activity in mice, antiviral activity in infected cell cultures, CNS stimulant activity in mice, and hypoglycemic activity in rats. The only biological activity exhibited by these compounds was a slight tendency to lower blood sugar levels in glucose‐primed, fasted rats. This activity may be attributable to their structural similarity to the sulfonylurea hypoglycemics.

Original languageEnglish (US)
Pages (from-to)1379-1381
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume62
Issue number8
DOIs
StatePublished - Aug 1973
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • 1‐(Arylsulfonyl)‐3,5‐dialkyl‐s‐triazine‐2,4,6‐(1H,3H5,H)‐triones—synthesized and screened as potential hypoglycemic agents
  • Hypoglycemic agents, potential—synthesis and screening of 1‐(arylsulfonyl)‐3,5‐dialkyl‐s‐triazine‐2,4,6‐(1H,3H,5H)‐triones
  • Triazine derivatives—synthesis as potential hypoglycemic agents and screening of 1‐(arylsulfonyl)‐3,5‐dialkyl‐s‐triazine‐2,4,6‐(1H,3H,5H)‐triones

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