Synergistic catalysis: A powerful synthetic strategy for new reaction development

Anna E. Allen, David W.C. MacMillan

Research output: Contribution to journalReview articlepeer-review

991 Scopus citations


Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the efficiency of existing transformations, and (III) create or improve catalytic enantioselectivity where stereocontrol was previously absent or challenging. This perspective aims to highlight these benefits using many of the successful examples of synergistic catalysis found in the literature.

Original languageEnglish (US)
Pages (from-to)633-658
Number of pages26
JournalChemical Science
Issue number3
StatePublished - Mar 2012

All Science Journal Classification (ASJC) codes

  • General Chemistry


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