Synchrony of Bird Migration with Global Dispersal of Avian Influenza Reveals Exposed Bird Orders

Qiqi Yang, Ben Wang, Phillipe Lemey, Lu Dong, Tong Mu, R. Alex Wiebe, Fengyi Guo, Nídia Sequeira Trovão, Sang Woo Park, Nicola Lewis, Joseph L.H. Tsui, Sumali Bajaj, Yachang Cheng, Luojun Yang, Yuki Haba, Bingying Li, Guogang Zhang, Oliver G. Pybus, Huaiyu Tian, Bryan Grenfell

Research output: Contribution to journalArticlepeer-review

Abstract

Highly pathogenic avian influenza virus (HPAIV) A H5, particularly clade 2.3.4.4, has caused worldwide outbreaks in domestic poultry, occasional spillover to humans, and increasing deaths of diverse species of wild birds since 2014. Wild bird migration is currently acknowledged as an important ecological process contributing to the global dispersal of HPAIV H5. However, this mechanism has not been quantified using bird movement data from different species, and the timing and location of exposure of different species is unclear. We sought to explore these questions through phylodynamic analyses based on empirical data of bird movement tracking and virus genome sequences of clade 2.3.4.4 and 2.3.2.1. First, we demonstrate that seasonal bird migration can explain salient features of the global dispersal of clade 2.3.4.4. Second, we detect synchrony between the seasonality of bird annual cycle phases and virus lineage movements. We reveal the differing exposed bird orders at geographical origins and destinations of HPAIV H5 clade 2.3.4.4 lineage movements, including relatively under-discussed orders. Our study provides a phylodynamic framework that links the bird movement ecology and genomic epidemiology of avian influenza; it highlights the importance of integrating bird behavior and life history in avian influenza studies.

Original languageEnglish (US)
Article number1126
JournalNature communications
Volume15
Issue number1
DOIs
StatePublished - Dec 2024

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy

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