Subversion of the actin cytoskeleton during viral infection

Matthew P. Taylor; Orkide O. Koyuncu; Lynn W. Enquist

doi:10.1038/nrmicro2574

Subversion of the actin cytoskeleton during viral infection

Matthew P. Taylor, Orkide O. Koyuncu, Lynn W. Enquist

Research output: Contribution to journal › Review article › peer-review

316 Scopus citations

Abstract

Viral infection converts the normal functions of a cell to optimize viral replication and virion production. One striking observation of this conversion is the reconfiguration and reorganization of cellular actin, affecting every stage of the viral life cycle, from entry through assembly to egress. The extent and degree of cytoskeletal reorganization varies among different viral infections, suggesting the evolution of myriad viral strategies. In this Review, we describe how the interaction of viral proteins with the cell modulates the structure and function of the actin cytoskeleton to initiate, sustain and spread infections. The molecular biology of such interactions continues to engage virologists in their quest to understand viral replication and informs cell biologists about the role of the cytoskeleton in the uninfected cell.

Original language	English (US)
Pages (from-to)	427-439
Number of pages	13
Journal	Nature Reviews Microbiology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1038/nrmicro2574
State	Published - Jun 2011

All Science Journal Classification (ASJC) codes

General Immunology and Microbiology
Infectious Diseases
Microbiology

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title = "Subversion of the actin cytoskeleton during viral infection",

abstract = "Viral infection converts the normal functions of a cell to optimize viral replication and virion production. One striking observation of this conversion is the reconfiguration and reorganization of cellular actin, affecting every stage of the viral life cycle, from entry through assembly to egress. The extent and degree of cytoskeletal reorganization varies among different viral infections, suggesting the evolution of myriad viral strategies. In this Review, we describe how the interaction of viral proteins with the cell modulates the structure and function of the actin cytoskeleton to initiate, sustain and spread infections. The molecular biology of such interactions continues to engage virologists in their quest to understand viral replication and informs cell biologists about the role of the cytoskeleton in the uninfected cell.",

author = "Taylor, {Matthew P.} and Koyuncu, {Orkide O.} and Enquist, {Lynn W.}",

note = "Funding Information: The authors acknowledge M. Way, W. Bohn, K. Gruenwald and K. DeMali for generously providing the original electron micrographs. They also appreciate the guidance and encouragement from all members of the Enquist laboratory. L.W.E. and O.O.K. are supported by the US National Institutes of Health grants R37 NS033506-16 and R01 NS060699-03. M.P.T. is supported by an American Cancer Society Postdoctoral Research Fellowship (PF-10-057-01-MPC).",

year = "2011",

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N2 - Viral infection converts the normal functions of a cell to optimize viral replication and virion production. One striking observation of this conversion is the reconfiguration and reorganization of cellular actin, affecting every stage of the viral life cycle, from entry through assembly to egress. The extent and degree of cytoskeletal reorganization varies among different viral infections, suggesting the evolution of myriad viral strategies. In this Review, we describe how the interaction of viral proteins with the cell modulates the structure and function of the actin cytoskeleton to initiate, sustain and spread infections. The molecular biology of such interactions continues to engage virologists in their quest to understand viral replication and informs cell biologists about the role of the cytoskeleton in the uninfected cell.

AB - Viral infection converts the normal functions of a cell to optimize viral replication and virion production. One striking observation of this conversion is the reconfiguration and reorganization of cellular actin, affecting every stage of the viral life cycle, from entry through assembly to egress. The extent and degree of cytoskeletal reorganization varies among different viral infections, suggesting the evolution of myriad viral strategies. In this Review, we describe how the interaction of viral proteins with the cell modulates the structure and function of the actin cytoskeleton to initiate, sustain and spread infections. The molecular biology of such interactions continues to engage virologists in their quest to understand viral replication and informs cell biologists about the role of the cytoskeleton in the uninfected cell.

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Subversion of the actin cytoskeleton during viral infection

Abstract

All Science Journal Classification (ASJC) codes

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