Study of viral pathogenesis in humanized mice

Jenna M. Gaska, Alexander Ploss

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Many of the viral pathogens that cause infectious diseases in humans have a highly restricted species tropism, making the study of their pathogenesis and the development of clinical therapies difficult. The improvement of humanized mouse models over the past 30 years has greatly facilitated researchers' abilities to study host responses to viral infections in a cost effective and ethical manner. From HIV to hepatotropic viruses to Middle East Respiratory Syndrome coronavirus, humanized mice have led to the identification of factors crucial to the viral life cycle, served as an outlet for testing candidate therapies, and improved our abilities to analyze human immune responses to infection. In tackling both new and old viruses as they emerge, humanized mice will continue to be an indispensable tool.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalCurrent Opinion in Virology
Volume11
DOIs
StatePublished - Apr 2015

All Science Journal Classification (ASJC) codes

  • Virology

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