TY - JOUR
T1 - Study of viral pathogenesis in humanized mice
AU - Gaska, Jenna M.
AU - Ploss, Alexander
N1 - Funding Information:
We would like to thank Florian Douam, Benjamin Winer, and Qiang Ding for their helpful discussion and comments on drafts of this paper. Work in the laboratory is in part supported by grants from the National Institutes of Health ( 2 R01 AI079031-05A1 , 1 R01 AI107301-01 , 1 R56 AI106005-01 ), the Walter Reed Army Institute of Research , the Bill and Melinda Gates Foundation and the Grand Challenge Program of Princeton University . JMG is supported by co-funding from NIAID on iNRSA 5T32GM007388. We apologize to all colleagues whose work could not be cited due to space constraints.
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/4
Y1 - 2015/4
N2 - Many of the viral pathogens that cause infectious diseases in humans have a highly restricted species tropism, making the study of their pathogenesis and the development of clinical therapies difficult. The improvement of humanized mouse models over the past 30 years has greatly facilitated researchers' abilities to study host responses to viral infections in a cost effective and ethical manner. From HIV to hepatotropic viruses to Middle East Respiratory Syndrome coronavirus, humanized mice have led to the identification of factors crucial to the viral life cycle, served as an outlet for testing candidate therapies, and improved our abilities to analyze human immune responses to infection. In tackling both new and old viruses as they emerge, humanized mice will continue to be an indispensable tool.
AB - Many of the viral pathogens that cause infectious diseases in humans have a highly restricted species tropism, making the study of their pathogenesis and the development of clinical therapies difficult. The improvement of humanized mouse models over the past 30 years has greatly facilitated researchers' abilities to study host responses to viral infections in a cost effective and ethical manner. From HIV to hepatotropic viruses to Middle East Respiratory Syndrome coronavirus, humanized mice have led to the identification of factors crucial to the viral life cycle, served as an outlet for testing candidate therapies, and improved our abilities to analyze human immune responses to infection. In tackling both new and old viruses as they emerge, humanized mice will continue to be an indispensable tool.
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U2 - 10.1016/j.coviro.2015.01.002
DO - 10.1016/j.coviro.2015.01.002
M3 - Review article
C2 - 25618248
AN - SCOPUS:84921456882
SN - 1879-6257
VL - 11
SP - 14
EP - 20
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -