Structure of the α-fetoprotein gene in the mouse

M. B. Gorin, S. M. Tilghman

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The mouse α-fetoprotein mRNA is the product of a single-copy gene whose mRNA coding sequences are represented discontinuously in the genome. Several EcoRI genomic fragments which contain portions of the α-fetoprotein gene have been cloned by using the EK2 vector λgt WES.λB. In addition, a mouse genomic library has been screened to obtain a 15.75-kilobase segment of DNA that includes more than 85% of the α-fetoprotein coding sequence. Analyses by restriction endonuclease mapping and electron microscopy showed that the mRNA sequence is interrupted by at least 11 intervening sequences which occupy 90% of the cloned DNA.

Original languageEnglish (US)
Pages (from-to)1351-1355
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume77
Issue number3 I
DOIs
StatePublished - 1980

All Science Journal Classification (ASJC) codes

  • General

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