Structure-function relationship of the voltage-gated calcium channel Cav1.1 complex

Jianping Wu, Nieng Yan, Zhen Yan

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Voltage-gated calcium (Cav) channels are miniature membrane transistors that convert membrane electrical signals to intracellular Ca2+ transients that trigger many physiological events. In mammals, there are ten subtypes of Cav channel, among which Cav1.1 is the first Cavα1 to be cloned. Cav1.1 is specified for the excitation–contraction coupling of skeletal muscles, and has been a prototype in the structural investigations of Cav channels. This article summarized the recent advances in the structural elucidation of Cav1.1 and the mechanistic insights derived from the 3.6 Å structure obtained using single-particle, electron cryomicroscopy. The structure of the Cav1.1 complex established the framework for mechanistic understanding of excitation–contraction coupling and provides the template for molecular interpretations of the functions and disease mechanisms of Cav and Nav channels.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages23-39
Number of pages17
DOIs
StatePublished - 2017
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume981
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • Ca1.1
  • DHPR
  • Structure
  • Voltage-gated calcium channel

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    Wu, J., Yan, N., & Yan, Z. (2017). Structure-function relationship of the voltage-gated calcium channel Cav1.1 complex. In Advances in Experimental Medicine and Biology (pp. 23-39). (Advances in Experimental Medicine and Biology; Vol. 981). Springer New York LLC. https://doi.org/10.1007/978-3-319-55858-5_2