Structure and mechanism in membrane trafficking

Frederick M. Hughson, Karin M. Reinisch

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Cell biologists have long been interested in understanding the machinery that mediates movement of proteins and lipids between intracellular compartments. Much of this traffic is accomplished by vesicles (or other membranous carriers) that bud from one compartment and fuse with another. Given the pivotal roles that large protein complexes play in vesicular trafficking, many recent advances have relied on the combined use of X-ray crystallography and electron microscopy. Here, we discuss integrated structural studies of proteins whose assembly shapes membranes into vesicles and tubules, before turning to the so-called tethering factors that appear to orchestrate vesicle docking and fusion.

Original languageEnglish (US)
Pages (from-to)454-460
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume22
Issue number4
DOIs
StatePublished - Aug 2010

All Science Journal Classification (ASJC) codes

  • Cell Biology

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