Structural Insights into the Mechanism of Dynamin Superfamily Proteins

John R. Jimah, Jenny E. Hinshaw

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis. They also function in the innate immune response to pathogens and in organizing the cytoskeleton. In this review, we summarize the current understanding of the molecular mechanism of DSPs, with emphasis on the structural basis of function. Studies from the past decade on the structure and mechanism of DSPs enable comparative analysis of shared mechanisms and unique features of this protein family.

Original languageEnglish (US)
Pages (from-to)257-273
Number of pages17
JournalTrends in Cell Biology
Volume29
Issue number3
DOIs
StatePublished - Mar 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology

Keywords

  • dynamin
  • endocytosis
  • innate immunity
  • membrane fission
  • membrane fusion
  • mitochondria

Fingerprint

Dive into the research topics of 'Structural Insights into the Mechanism of Dynamin Superfamily Proteins'. Together they form a unique fingerprint.

Cite this