Abstract
Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 420-425 |
| Number of pages | 6 |
| Journal | RSC Chemical Biology |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| State | Published - Feb 7 2022 |
All Science Journal Classification (ASJC) codes
- Chemistry (miscellaneous)
- Biochemistry
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology (miscellaneous)
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