@article{8d0fd0dcbf344924a7ae2f1b82dbfd18,
title = "Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines",
abstract = "Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies.",
author = "Horwitz, {Samantha M.} and Blue, {Tamra C.} and Ambarian, {Joseph A.} and Shotaro Hoshino and Seyedsayamdost, {Mohammad R.} and Davis, {Katherine M.}",
note = "Funding Information: This work was supported by the National Institutes of Health (Pathway to Independence Award 4R00GM129460 to K. M. D. and R01GM140034 to M. R. S.), the Beckman Young Investigator Program (to K. M. D.), Emory University start-up funds, and by a JSPS Overseas Research Fellowship (grant 201960049 to S. H.). GM/CA@APS has been funded by the National Cancer Institute (ACB-12002) and the National Institute of General Medical Sciences (AGM-12006, P30GM138396). This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. The Eiger 16M detector at GM/CA-XSD was funded by NIH grant S10 OD012289. Publisher Copyright: {\textcopyright} 2022 The Author(s).",
year = "2022",
month = feb,
day = "7",
doi = "10.1039/d1cb00255d",
language = "English (US)",
volume = "3",
pages = "420--425",
journal = "RSC Chemical Biology",
issn = "2633-0679",
publisher = "Royal Society of Chemistry",
number = "4",
}